![]() Despite the early safety challenges in Phase 2 ( 2), the clinical development of recombinant human (r)IL-12 and related compounds has been extensive in cancer and immunotherapy indications over the past two decades ( 3, 4).Īs a cytokine, IL-12 has multiple effector functions that bridge the innate and adaptive immune responses in cancer ( 5) to promote the activation of NK and NKT cells and to polarize CD4 + and CD8 + T cells. Its extended half-life leads to a prolonged but controlled IFNγ response, which may be important for tumor control in patients.Ĭlinical trial registration:, identifier NCT05408572.ġ Introduction: Interleukin-12 and SON-1010įirst discovered in the late 1980s, Natural Killer Cell Stimulatory Factor, eventually renamed interleukin-12 (IL-12), is a proinflammatory cytokine produced by activated phagocytes and dendritic cells and is a key regulator of cell-mediated immunity ( 1). There was no evidence of cytokine release syndrome based on minimal participant symptoms and responses observed with other cytokines.Ĭonclusion: SON-1010, a novel presentation for rIL-12, was safe and well-tolerated in healthy volunteers up to 300 ng/kg. ![]() PK analysis showed two-compartment elimination in SB102 with mean T ½ of 104 h, compared with one-compartment elimination in SB101, which correlated with prolonged but controlled and dose-related increases in interferon-gamma (IFNγ). As expected with rIL-12, initial decreases in neutrophils and lymphocytes returned to baseline by days 9-11. All TEAEs were transient and no other dose relationship was noted. Results: Participants receiving SON-1010 at 100 ng/kg or higher tolerated the injection but generally experienced more treatment-emergent adverse effects (TEAEs) than those receiving the lowest dose. A non-compartmental analysis of PK was performed and correlations with the PD results were explored, along with a comparison of the SON-1010 PK profile in SB101. Safety was reviewed after day 22, before enrolling the next cohort. SON-1010 at 50-300 ng/kg or placebo administered subcutaneously on day 1 was studied at a ratio of 6:2, starting with two sentinels participants were followed through day 29. Methods: SB102 (NCT05408572) focused on safety, tolerability, pharmacokinetic (PK), and pharmacodynamic (PD) endpoints. After initiating a dose-escalation trial in patients with cancer (SB101), a randomized, double-blind, placebo-controlled, single-ascending dose (SAD) phase 1 trial in healthy volunteers (SB102) was conducted. We developed a strategy to extend the rIL-12 T ½ that depends on binding albumin in vivo to target tumor tissue, using single-chain rIL-12 linked to a fully human albumin binding (F HAB) domain (SON-1010). Despite some signs of efficacy since then, most rIL-12 clinical trials have encountered hurdles such as short terminal elimination half-life (T ½), limited tumor microenvironment targeting, and substantial systemic toxicity. Unexpected toxicity in the first phase 2 study required careful attention to revised dosing strategies. ![]() 6Nucleus Network Pty Ltd, Melbourne, VIC, Australiaīackground: The benefits of recombinant interleukin-12 (rIL-12) as a multifunctional cytokine and potential immunotherapy for cancer have been sought for decades based on its efficacy in multiple mouse models. ![]()
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![]() ![]() Oxidized and waxed variants of all the above.The Copper family of blocks has been expanded, including:.Powering Crafter with Redstone signal makes it craft and output the item.Moving items into crafter from Hopper or Dropper distributes them evenly instead of first filling the first stack.A Comparator connected to a Crafter now outputs a signal that is equal to the amount of non-empty slots plus disabled slots.Crafter has distinct sounds for crafting and failing.Crafter uses distinct particles when crafting.Crafter can be crafted with Redstone Dust, Iron Ingots, Crafting Table, and Dropper.Vindicators and Evokers can no longer be spawned in a Peaceful world ( MCPE-124736).Added missing references to Netherite related items ( MCPE-90770, MCPE-165370).Removed obsolete references to "Old world".Completely remodeled the "How to Play" screen and created a new "Encyclopedia" screen.The Bat now has a new look, thanks to an updated model, animations, and texture.Increased the maximum stack size of identical Decorated Pots to 64.Decorated Pots can be smashed by projectiles, which cause them to shatter and drop their content.Player interactions with Decorated Pots cause Decorated Pots to wobble and emit a vibration of frequency 11.Decorated Pots have no user interface and need to be broken to retrieve or discover their content.Players can interact with Decorated Pots to insert items into them. ![]() Comparators can now read the number of items in Decorated Pots.Hoppers, Hopper Minecarts, and Droppers can now insert and/or extract items from Decorated Pots.Decorated Pots now store up to a single stack of items.New Features: Improvements to Decorated Pots Your thoughts on the game continue to shape new updates so please upvote and report any new bugs at and leave us your feedback at. A wealth of fixes, improvements, and technical changes.The ‘How to Play’ screen has been completely revamped into the ‘Encyclopedia’ screen.New experimental features from the upcoming 1.21 update, including the Crafter and new Copper blocks.Improvements to Decorated Pots, like the ability to place items inside and smash them with projectiles.The latest Minecraft update brings a brand new look for bats, smashable pots, and some new experimental features like the crafter block. ![]() ![]()
![]() ![]() I can do all of my adjustments while in Windows, while doing something.NZXT CAM also has a guest mode (at least for now).NZXT CAM doesn't need admin privileges to run (I'm very weary of programs that need it).So the solution I've settled on, as I put in my previous post, is NZXT's fan controller with NZXT CAM. I've tried the motherboard manufacturer's fan control utility, but it doesn't work.And I'd rather not rely on the video card warming up the rest of the system to heat up the main input so that the fans start working harder. I would rather adjust the fans based on the temperature of that, not the CPU or the motherboard. This is not adequate for me because when gaming, which is the most common load I put on it, the hottest thing is the video card. I already mentioned that motherboards only have the CPU or the board itself as the temperature input.And even then I could just use a Y-splitter. A fan hub is pretty worthless to me because most motherboards have enough headers for the amount of fans I have.My motherboard is an ASRock B550 Steel Legend. My bottom intake and rear exhaust are based on GPU temp with a higher fan curve in place.Ĭlick to expand.So as a reference point, I have a Fractal Design Meshify C with 2x140mm fans in the front and a 1x120mm fan in the back. My latest build uses a hub for grouping my front 3x intakes to a single header that are reading my CPU temperature to keep a nice cool quiet wall of air flowing towards the top-mounted radiator and across other components. It will usually be different for every setup ĭifferent case layout, different fan models, different GPU & CPU generating more heat than average, etc.įor the passed 10 years or so i have kept separate fans with separate profiles with some blowing cooler air into my GPUs and others carrying cooler air towards/through my CPU coolers.Ī few of my latest builds have been setup with īottom & front-bottom intake fans and rear exhaust based on GPU temperature,įront-mid/top fans aimed more toward the radiator or CPU heatsink will be based on CPU temp. I haven't tried Corsair's iCUE recently, but Corsair is the only alternative I'm aware of that has a fan controller and last I used iCUE, it required elevated privileges to run.Ĭlick to expand.if your board's BIOS only offers CPU or System as the base source you may want to look into some motherboard control software that may allow other sensors to be read and included. Of note, NZXT CAM which you need to configure the fan controller can also run without elevated privileges. Plus I can adjust the fan speeds while in Windows and running a load to find a sweet spot between fan noise and component temperature. I think I'd rather have my cooling based on the hottest part of the system. The GPU on the other hand will easily dissipate 3-4 times that amount. To put in perspective, the CPU dissipates maybe around 40-50W. The fan controller allows me to adjust the case fans based on the video card temperature, which during gaming I find is more important to monitor and adjust the fans for. ![]() Neither of these output enough heat in my system to be of concern. I bought an NZXT fan controller because I don't like how your only options for temperature source at the UEFI level is either the CPU or the motherboard (which I presume is the chipset). ![]() ![]() ![]() I know you want to rush off and see what the porn movie sites I reviewed offer, so I am going to shut up now and let you do your thing.Welcome to Porn Week, Mashable's annual close up on the business and pleasure of porn. I want to spend some time in a locked room with you. Why not take the time to read our reviews and get a feel for the porn movie sites out there that might be worth pointing your loaded cock at! Is that All? I cant wait to put on a movie, grab some lube and popcorn! The latter has some sex documentaries that a great cumming historian like you will no doubt want to see! PeekVids are good too, as are FullXCinema. Updates are frequent and content quality is great. They have an outstanding site design, plus titles like Moms Suck Teens 5, Dirty Wives Clubs 27, Seduced By My Best Friend and She’s So Small. However, I happen to have a weakness for DailyXMovies. There you can presumably cum so hard you could break a bone! Which porn movie site would I recommend? Not to worry, if you have money to spend and nowhere to spend it on, we intend to review some paid porn movie sites soon. Doing that is easy, though ads have a propensity to interrupt you just when you are about to aim for the sky and shoot off a load big enough to block the sun! All the sites we reviewed are free and to watch them it is often necessary to disable your adblocker. Well, how much money you got? Most such porn movie sites are free and you pay for access by getting ads shoved in your face. Porn movie sites don’t have this limitation, as they predominantly feature professional quality porn with all the bells and whistles.Ĭumming to such content has to be the sweetest and most earth-shaking act your cock can engage in and you can take that to the bank and demand a stamp on it! Free or paid or whats the catch ? See, quite a lot of content on the majority of XXX sites are user-submitted and of middling quality. Videos on such sites are often hours long, which means you can fap and fap till your cock gets tired and runs away from you! By the way dude, If it only takes you a minute to cum then you should be practicing to hold off longer!Īnother appeal is that the content quality is most often superior to what is found on regular porn sites. You are asking me what’s the appeal of such sites? Like you can’t figure it out for yourself? Well, the main appeal of porn movie sites is that you can get full-length content there. That means all you have to do to make your day awesome is to play a video from such site while sitting on a couch with plenty of Vaseline nearby, plus a big bucket to collect all the hefty globs of cum that will be speeding out of your hard cock looking for a new home on your ceiling, floor and walls! Yo Porn Guy it only takes me 1 minute to bust why watch a whole porn movie? ![]() They however tend to be in the minority, with most or all of the content being full-length and hours long. ![]() However, there are short XXX movies on porn movie sites. At such sites, you get to view hours long videos that make your woody grow large enough to be used to batter down a castle wall! A porn movie site on the other hand mostly deals with full-length XXX movies. What sets an XXX movie site apart from a regular porn site is that the latter has all kinds of content, which lasts for seconds or hours in some cases. Indeed, the two are often mistaken for each other. You are the real XXX OG! If you haven’t then I am sorry to tell you that you are so naive even Jada Fire would refuse to shit on your face even if you were ready to pay her a million dollars!įor those of you who have never heard of porn movie sites, such sites are almost the same as your regular porn site. If you have heard of such sites then congrats. And yes, the two are different in ways large and small. See, have something called a porn movie site been mentioned around you? I didn’t say a porn site, but rather a porn movie site. Yes, leave your cock alone for once and focus here. 17+ Best Free Porn Movie Sites – Free XXX Movie Sites!Ĭome on, pay some attention. ![]() ![]() ![]() In graphics, Terrain LOD has a huge impact, so keep that at 100. If you are getting decent performance with these settings, start to tweak from there. Weather to Preset (Clear or whatever to test) Try the following as a baseline to see how your performance is: *1:58:52 - I went into the settings and check *Ģ:14:21 - I open the taskmanger and check for Performance (not much open, “only” 28 of GPU and 48% of CPU and yes, I know this is the average for all threads)Ģ:19:25 - Enabling the FPS count in MSFS.Ģ:22:44 - I’m opening HWMonitor to check for temps.Ģ:36:32 - CTD when trying to enter ESC-Menu Anyway, i’ll link the Video below and will give timestamps so you can see.ġ:37:00 - first stutters appear - which i’ve never experienced beforeġ:45:54 - Plane starts to bank like crazy (probably because of bad performance and game can’t process AP inputs) - never experienced beforeġ:47:37 - I change weather because i think it’s just turbulence. The Performance in Zürich is quite normal for my system, which i think is kind of weird for the components. I was streaming for a friend in the PMDG 737 to Istanbul. I disabled programs in backround - i’am desperate. I deleted many things from community folder and checked for viruses. I tried low settings and mid setting with pretty bad results - almost no changes. ![]() And yes, i changed my settings multiple times. I watched Videos, changed values in regedit and Videocard driver etc. Before, my performance was relatively bad compared to poeple with worse components.īefore I registered here, I read multiple threads for a possbile increase of performance in the sim. Just a few hours ago, i was flying the PMDG 737 and suddendly heavy stutter and one-digit FPS kicked in. I’ve been experiencing very low performance lately altough my PC is quite good.
![]() ![]() ![]() Visit for continuing coverage of the delivery and display of NASA's retired space shuttles.įollow collectSPACE on Facebook and Twitter collectSPACE and editor Robert Pearlman robertpearlman. As the Space Shuttle Endeavour exhibition in the California Science Center’s Samuel Oschin Pavilion closes its doors to Los Angeles, the center prepares for the final move, vertical lift and. EndeavourLA is the California Science Center Foundation’s 400 million fundraising campaign that has enabled the acquisition and temporary display of Space Shuttle Endeavour and supports our plans to build the Samuel Oschin Air and Space Center and sustain ongoing exhibits, programs and operations. "Their generous donation ensures that space shuttle Endeavour has a world-class facility in which to reside, a place that will inspire youth to dream of future space exploration, stimulating science and math education for generations, and stimulating tourism to Los Angeles along with it." "On behalf of the City of Los Angeles, I express heartfelt thanks," Villaraigosa remarked. ![]() Construction of the Samuel Oschin Air and Space Center is expected to take three years. Los Angeles Mayor Antonio Villaraigosa came to the CSC to thank the Oschin Family Foundation for their support. The Shuttle Gallery will display the Endeavour space shuttle mated with a pair of real solid rocket boosters and the 154ft-long external tank ET-94, which weighs more than 65,000lb (29,483.5kg). Mercury-Redstone 2 capsule which carried Ham, a chimpanzee, the first great ape in space (1961) Gemini 11 capsule, flown by Pete Conrad and Richard F. His success in a range of enterprises, from manufacturing to real estate, enabled his adventures to Africa, the North Pole, the Amazon and a 100-mile trek retracing Hannibal's crossing of the Alps. Space Shuttle Endeavour in the temporary Samuel Oschin Pavilion (Feb 2023) The Gemini 11 space capsule, flown in 1966. Samuel Oschin dedicated himself to improving the quality of life in the Los Angeles community. "This is Sam's vision and represents truly everything my husband dreamed, loved and believed in." The last piece of the Go For Stack puzzle will be moving the roughly 176,000 pound orbiter from its temporary home at the Samuel Oschin Pavilion, where it’s been on public display for more. "Today pays tribute first and foremost to my husband, and his passion for discovery, philanthropy, and the pursuit of knowledge," Lynda Oschin said. 21, 2012, during a4.5-hour aerial tour over California. The Space Shuttle Endeavour is on display at the Samuel Oschin Pavilion at the California Science Center during a media preview ahead of the opening of Endeavour Fest, commemorating the one-year. NASA shut down space shuttle Endeavour for the final time on May 11, 2012, but not before giving the chance to photograph the retired spacecraft's powered-on flight deck. NASAs space shuttle Endeavour flies over Los Angeles International Airport while riding piggyback atop its Shuttle Carrier Aircraft on Sept. A last look at a fully lit space shuttle. ![]() ![]() Consider adding a 'teacher tips' section where educators can share creative ways they've used the clipart in their classrooms. stylish ink hand drawn for decoration, home decor, wall art, poster, fashion and textile. Elephant art abstract sketch and drawing. Jungle animals line art including monkey, tiger, zebra, giraffe, lion, elephant, snake, deer and peacock. Minimalist black linear sketch isolated on white background. Outline wild safari animals vector illustration for coloring. Cute elephant in continuous line art drawing style. The intuitive search function and categorized clipart sets save time. Browse 160+ baby elephant outline stock illustrations and vector graphics available royalty-free, or start a new search to explore more great stock images and vector art. 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Cute Elephant - Vector File Illustration of cute baby elephant cartoon sitting Baby elephants Vector background with elephant. ![]() ![]() Each month shows the number of weeks, Sundays, holidays, and the number of days. A month begins with date 1 and ends on either 28 th, 29 th, 30 th, or 31 st, depending upon the rotation of the moon. A month calendar is, therefore, a document that contains a fixed, standardized pattern of display of the periodic months. ![]() These are regarded as the period of the completion of one lunar cycle or the moon’s rotational cycle. In the lunar calendar, each year has been divided into 12 months. Why is a monthly calendar beneficial for us?.Adorable Template with your Own Photo on Every Month Page.Template with an Inspirational Quote for each Month. ![]() Beautiful Design with different Season Photo for each Month.Download Templates for 2024 in MS Word Format.The calendars these days have, however, turned to online ones or the ones we keep on our mobile devices to help us read the day and month. We all remember seeing those beautiful, colorful calendars hung on the house walls that told us the months and dates. The use of calendars and how to read them to know the day for us is one of the most vital parts of our lives. One of the very first concepts we get to learn as kids is the concept of date, days, and time! Get ready to transform the way you plan your days ? download now! Best part? It’s all here for you, absolutely free. 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Press and hold the space bar on your keyboard to pull the plunger back. You can also click the left mouse button on the ball and drag it wherever on. Upon completing a mission, some of the blue lights in a circle in the middle of the table turn on. Windows XP je dnes ji mrtvý operaní systém, který byl kdysi velice oblíbený. Press M to show how much system memory is available. The "fuel" lights go out one by one at a time interval, and can be re-lit by having the ball go over them, or all at once by going up the launch ramp again. Missions end either by being completed, or by being aborted due to running out of "fuel", as indicated by the lights in the passage that passes under the launch ramp. Some missions involve a number of steps which must be completed in sequence. Each mission has a set number of things for players to do, such as hitting the "attack bumpers" (which are a set of four bumpers at the top of the table) eight times (this is the "target practice" mission). PINBALL, also known as PINBALL.MID, Pinball.mid, PINBALL.mid, Rock2.mid or ROCK2.MID, is a midi file found hidden in the C Drive at Program FilesWindows NTPinball as the BGM of the 3D Pinball for Windows - Space Cadet, a game that can be found pre-installed on Windows 95 Plus, Windows NT 4. Players accept a mission by hitting "mission targets" which select which mission they will take, and by going up the "launch ramp". When my brother and I got Windows XP and found Space Cadet pinball was excluded included we were ecstatic When we found out that they had. One of the greatest offline games that I miss dearly. Or check it out in the app stores TOPICS. Players can attain nine different ranks (listed from lowest to highest): Cadet, Ensign, Lieutenant, Captain, LT Commander, Commander, Commodore, Admiral, and Fleet Admiral. Scan this QR code to download the app now. You can still download it) 7. The table features the player as a member of a space fleet that completes missions to increase rank. Microsoft Windows Pinball - Space Cadet was first introduced in Microsoft Plus 95 as 3D Pinball - Space Cadet and features 3D graphics and addictive gameplay. Anybody remember 3D Pinball Space Cadet from Windows XP (P.S. ![]() |
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